Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC071
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-15 08:14
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment new patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 41 individuals with a value less than 0.78 were subsequently diagnosed with PD. That is, 97.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.78 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 2, 'TN': 2, 'TP': 40, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 38, 'TN': 29, 'TP': 4, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 17, 'TN': 10, 'TP': 25, 'FP': 20}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.34
timePerCircleCoV 0.143582
timePerCircleSlope -0.0266195
meanError 1.35649
tremorFreq 5.46875
tremorRelPower 24.0581
tremorGyroAmpMean 0.0108707
tremorGyroAmpSlope -0.000100714
tremorGyroAmpCoV 0.414831
tremorCoordAmpMean 0.0291816
tremorCoordAmpSlope -2.85644e-05
tremorCoordAmpCoV 0.282254
tremorAccAmpMean 0.0238016
tremorAccAmpSlope 0.00265765
tremorAccAmpCoV 0.379259
tremorPcRelVar 0.583603
tremorPcX 0.726527
tremorPcY 0.687138

Circle Segment 1

Duration 10.96 s, Accuracy Estimate 1.876 (lower is better)

Circle Segment 2

Duration 16.52 s, Accuracy Estimate 1.451 (lower is better)

Circle Segment 3

Duration 14.08 s, Accuracy Estimate 1.335 (lower is better)

Circle Segment 4

Duration 12.08 s, Accuracy Estimate 1.351 (lower is better)

Circle Segment 5

Duration 12.76 s, Accuracy Estimate 1.12 (lower is better)

Circle Segment 6

Duration 12.08 s, Accuracy Estimate 1.032 (lower is better)

Circle Segment 7

Duration 11.24 s, Accuracy Estimate 1.138 (lower is better)

Circle Segment 8

Duration 11.64 s, Accuracy Estimate 1.149 (lower is better)

Circle Segment 9

Duration 11.44 s, Accuracy Estimate 1.176 (lower is better)

Circle Segment 10

Duration 10.6 s, Accuracy Estimate 1.938 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 31.9956
timePerSpiralCoV 0.134928
timePerSpiralSlope -0.0315669
meanError 1.69927
tremorFreq 6.44531
tremorRelPower 27.8044
tremorGyroAmpMean 0.00724462
tremorGyroAmpSlope 0.00104903
tremorGyroAmpCoV 0.416368
tremorCoordAmpMean 0.039661
tremorCoordAmpSlope 0.0045781
tremorCoordAmpCoV 1.50844
tremorAccAmpMean 0.0228786
tremorAccAmpSlope 0.00113947
tremorAccAmpCoV 0.347976
tremorPcRelVar 0.622497
tremorPcX -0.990761
tremorPcY 0.135619

Spiral Segment 1

Duration 41.76 s, Accuracy Estimate 1.491 (lower is better)

Spiral Segment 2

Duration 33.36 s, Accuracy Estimate 1.832 (lower is better)

Spiral Segment 3

Duration 30.76 s, Accuracy Estimate 1.648 (lower is better)

Spiral Segment 4

Duration 30.88 s, Accuracy Estimate 1.751 (lower is better)

Spiral Segment 5

Duration 32.4 s, Accuracy Estimate 1.66 (lower is better)

Spiral Segment 6

Duration 29.08 s, Accuracy Estimate 1.779 (lower is better)

Spiral Segment 7

Duration 27.44 s, Accuracy Estimate 1.863 (lower is better)

Spiral Segment 8

Duration 34.16 s, Accuracy Estimate 1.554 (lower is better)

Spiral Segment 9

Duration 28.12 s, Accuracy Estimate 1.717 (lower is better)

Elel

eDurationMean 0.456324
eDurationStd 0.087172
eDurationStdnorm 0.191031
eDurationMedian 0.445
eDurationQuartdelta 0.115
eDurationQuartdeltanorm 0.258427
eDurationKurt 3.33838
eDurationTrenddiff -0.035
eDurationTrendratio 0.923913
eWidthMean 4.56644
eWidthStd 1.16163
eWidthStdnorm 0.254385
eWidthMedian 4.329
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.351351
eWidthKurt 3.36087
eWidthTrenddiff 0
eWidthTrendratio 1
eHeightMean 10.3855
eHeightStd 2.1221
eHeightStdnorm 0.204334
eHeightMedian 9.945
eHeightQuartdelta 2.106
eHeightQuartdeltanorm 0.211765
eHeightKurt 2.90695
eHeightTrenddiff 0.234
eHeightTrendratio 1.0241
eAspectMean 0.44468
eAspectStd 0.0965649
eAspectStdnorm 0.217156
eAspectMedian 0.447887
eAspectQuartdelta 0.168627
eAspectQuartdeltanorm 0.376495
eAspectKurt 2.35587
eAspectTrenddiff -0.0589314
eAspectTrendratio 0.870912
eSlantMean 0.0340326
eSlantStd 0.0985562
eSlantStdnorm 2.89593
eSlantMedian 0.0451153
eSlantQuartdelta 0.158463
eSlantQuartdeltanorm 3.51241
eSlantKurt 2.61578
eSlantTrenddiff -0.0113906
eRtopMean 0.836326
eRtopStd 0.0654728
eRtopStdnorm 0.0782862
eRtopMedian 0.837265
eRtopQuartdelta 0.107639
eRtopQuartdeltanorm 0.12856
eRtopKurt 2.68696
eRtopTrenddiff 0.00537634
eRbotMean 0.764655
eRbotStd 0.215154
eRbotStdnorm 0.281374
eRbotMedian 0.716518
eRbotQuartdelta 0.328482
eRbotQuartdeltanorm 0.458443
eRbotKurt 3.81577
eRbotTrenddiff 0.0857143
eRrightMean 0.916422
eRrightStd 0.0332427
eRrightStdnorm 0.0362745
eRrightMedian 0.918824
eRrightQuartdelta 0.0436551
eRrightQuartdeltanorm 0.047512
eRrightKurt 2.72331
eRrightTrenddiff 0.0119517
eRleftMean 0.328017
eRleftStd 0.0692775
eRleftStdnorm 0.211201
eRleftMedian 0.326432
eRleftQuartdelta 0.0801718
eRleftQuartdeltanorm 0.2456
eRleftKurt 3.28903
eRleftTrenddiff -0.0170068
lDurationMean 0.485676
lDurationStd 0.113695
lDurationStdnorm 0.234097
lDurationMedian 0.45
lDurationQuartdelta 0.18625
lDurationQuartdeltanorm 0.413889
lDurationKurt 2.31174
lDurationTrenddiff -0.025
lDurationTrendratio 0.946237
lWidthMean 4.89186
lWidthStd 0.738861
lWidthStdnorm 0.151039
lWidthMedian 5.031
lWidthQuartdelta 0.9945
lWidthQuartdeltanorm 0.197674
lWidthKurt 2.19889
lWidthTrenddiff 0.5265
lWidthTrendratio 1.1125
lHeightMean 14.1633
lHeightStd 1.89861
lHeightStdnorm 0.134051
lHeightMedian 14.274
lHeightQuartdelta 2.72025
lHeightQuartdeltanorm 0.190574
lHeightKurt 2.87815
lHeightTrenddiff 2.1645
lHeightTrendratio 1.16742
lAspectMean 0.349291
lAspectStd 0.0602775
lAspectStdnorm 0.172571
lAspectMedian 0.349593
lAspectQuartdelta 0.0811993
lAspectQuartdeltanorm 0.232268
lAspectKurt 2.51463
lAspectTrenddiff -0.0142903
lAspectTrendratio 0.959769
lSlantMean 0.0709825
lSlantStd 0.0982646
lSlantStdnorm 1.38435
lSlantMedian 0.0650407
lSlantQuartdelta 0.122949
lSlantQuartdeltanorm 1.89035
lSlantKurt 2.66354
lSlantTrenddiff 0.0549382
lRtopMean 0.882043
lRtopStd 0.0803011
lRtopStdnorm 0.0910399
lRtopMedian 0.90625
lRtopQuartdelta 0.106533
lRtopQuartdeltanorm 0.117554
lRtopKurt 3.19636
lRtopTrenddiff 0.0270547
lRbotMean 0.690876
lRbotStd 0.23198
lRbotStdnorm 0.335776
lRbotMedian 0.695652
lRbotQuartdelta 0.372554
lRbotQuartdeltanorm 0.535547
lRbotKurt 2.33188
lRbotTrenddiff -0.0796956
lRrightMean 0.943028
lRrightStd 0.0298385
lRrightStdnorm 0.0316412
lRrightMedian 0.951456
lRrightQuartdelta 0.0323242
lRrightQuartdeltanorm 0.0339733
lRrightKurt 2.65218
lRrightTrenddiff -0.00535406
lRleftMean 0.284602
lRleftStd 0.0895846
lRleftStdnorm 0.314771
lRleftMedian 0.262411
lRleftQuartdelta 0.141356
lRleftQuartdeltanorm 0.53868
lRleftKurt 1.97796
lRleftTrenddiff -0.0662215

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 1
sumTouchScores 23
meanMovementTime 0.814091
numTouches 23
undershootPercentage 0
overshootPercentage 0

FITTS Long Modified

meanTouchScore 0.916315
sumTouchScores 15.5774
meanMovementTime 1.20188
numTouches 17
undershootPercentage 5.88235
overshootPercentage 11.7647

ZigZag

numZigzags 5
timePerZigzagMean 52.328
timePerZigzagCoV 0.189742
timePerZigzagSlope -0.11512
meanError 1.89117
tremorFreq 5.07812
tremorRelPower 26.9612
tremorGyroAmpMean 0.0112548
tremorGyroAmpSlope 0.00195848
tremorGyroAmpCoV 0.403531
tremorCoordAmpMean 0.0294643
tremorCoordAmpSlope 0.00215922
tremorCoordAmpCoV 0.267546
tremorAccAmpMean 0.0227031
tremorAccAmpSlope 0.00221896
tremorAccAmpCoV 0.483326
tremorPcRelVar 0.658574
tremorPcX 0.144753
tremorPcY 0.989468

ZigZag Segment 1

Duration 64.72 s, Accuracy Estimate 1.878 (lower is better)

ZigZag Segment 2

Duration 55.2 s, Accuracy Estimate 1.864 (lower is better)

ZigZag Segment 3

Duration 55.0 s, Accuracy Estimate 1.97 (lower is better)

ZigZag Segment 4

Duration 49.04 s, Accuracy Estimate 1.866 (lower is better)

ZigZag Segment 5

Duration 37.68 s, Accuracy Estimate 1.877 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 15.968
timePerZigzagCoV 0.389996
timePerZigzagSlope -0.227455
zigzagHeightMean 72.1929
zigzagHeightCoV 0.00738869
zigzagHeightSlope -0.000471423
meanError 0.034546
tremorFreq 7.03125
tremorRelPower 22.7684
tremorGyroAmpMean 0.0148075
tremorGyroAmpSlope 0.00724687
tremorGyroAmpCoV 0.527082
tremorCoordAmpMean 0.058359
tremorCoordAmpSlope 0.0110862
tremorCoordAmpCoV 0.298776
tremorAccAmpMean 0.0249206
tremorAccAmpSlope 0.00885331
tremorAccAmpCoV 0.379908
tremorPcRelVar 0.839217
tremorPcX 0.112096
tremorPcY 0.993697

ZigZag Offset Segment 1

Duration 24.92 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 2

Duration 20.04 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 3

Duration 11.88 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 4

Duration 12.44 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 5

Duration 10.56 s, Accuracy Estimate 0.059 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.27}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.78}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.4394666610932687}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.5659210376220298}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44262119039553416}